The Raab-Graham Lab, led by Dr. Kimberly Raab-Graham, is a research laboratory based in Winston-Salem, NC, focused on understanding the molecular mechanisms involved in learning and memory. Their research explores the biological processes underlying cognition in neurological disorders such as major depressive disorder, Alzheimer's disease, autism spectrum disorder, and alcohol use disorder. Through their experimental approach, which ranges from molecules to behavior, they aim to identify new drug treatments that restore the balance of protein synthesis and synaptic efficacy.
The lab utilizes unbiased approaches like mass spectrometry and RNA sequencing to identify proteins and RNA near synapses, and develops assays to visualize protein synthesis in dendrites. Their findings provide insights into dynamic changes in ion channel expression, function, and behavior across animal models of disease, with plans to extend their studies to include nonhuman primates and humans at Wake Forest School of Medicine.
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